User:Caston/BlogEntry: 2010 November 02 14:48:42 UTC

High lactate found in brain aging
A new biomarker for brain aging appears to have been discovered: High brain lactic acid levels (at least in mice)

"High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio."

I'm not sure exactly why this happens but it seems to be related to increases in pyruvate to lactate conversion.

http://www.pnas.org/content/early/2010/10/25/1008189107

http://www.sciencedaily.com/releases/2010/11/101102083646.htm