Aging theory

SENS

Damage Rising with Age	Date	Reversable or obviatable by
Cell loss, Atropy	1955	Stem cells, growth factors, exercise
Nuclear mutations	1959/1982	WILT
Mutant Mitochondria	1972	Allotopic expression of 13 proteins
Death resistant cells	1965	Cell ablation reprogrammng
Extra cellular crosslinks	1981	AGE-breaking molecules enzymes
Extracellular junk	1907	Phagocytosis: beta-blockers
Intracellular junk	1959	Transgenic microbial hydrolases

Note: this is still under construction. New ideas welcome!

Damage Rising with Age	Date	Caused by	Reversable or obviatable by
Cell loss, atrophy	1955	Intracellular pathogens	target with anti-biotics?, antimicrobials? novel intracellular target synthetic drugs such as stapled peptides and riptides
Nuclear mutations	1959/1982	Intracellular pathogens	Kill pathogens. Make cells fuse together to repair genetic damage. Target cancerous cells with immune system or even certain viruses or trigger apoptosis using novel drugs.
Increased free radical production by mitochondria	1972	Increasing hostile cytoplasm	Kill biological pathogens in cytoplasm. RNAi
Death Resisant cells	165	Intracellular pathogens	Target with immune system.RNAi
Extra cellular crosslinks	1981	Biological pathogens. Modification of proteins. Immune reponse?	Reduce bacterial load with antimicrobials Fibroblast turnover.
Extra cellular junk	1907	Bacterial and calcified biofilms	Disrupt and destroy bacterial biofilms with antibiofilm agents
Intracellular junk	1959	Biological pathogens. Build up of junk that can't be degraded	Kill pathogens. Use enzyme replacement therapy or synthetic biologics such as Stapled peptides or RIPtides for intracellular targets